Why the study?
Reactive oxygen species and inflammatory mediators provoked by oxidative stress can promote the development of acute coronary syndrome.
Do patients with acute coronary syndrome have altered levels of inflammatory and oxidative stress biomarkers compared to healthy controls?
Do patients with acute coronary syndrome have altered levels of inflammatory and oxidative stress biomarkers compared to healthy controls?
Patients with acute coronary syndrome exhibit significantly increased inflammatory cytokines and reduced antioxidant capacity, highlighting the role of oxidative stress in ACS pathogenesis.
Lower antioxidants and higher cytokines in ACS patients suggest oxidative-inflammatory interplay; leaves open targeted trials.
Background: In response to oxidative stress, reactive oxygen species aggravate and activate different signaling mechanism and stimulate the release of different inflammatory mediators, and provoke the generation of oxidative stress, all of which can promote the development of acute coronary syndrome. Methodology: The study sample comprised of 76 ACS patients and 76 healthy controls. Blood samples of ACS patients and controls were collected to determine the serum concentration of antioxidants, and the serum levels of inflammatory biomarkers. Spectrophotometric method and ELISA kit method was used to measure these variables accordingly. Results: The results indicated a significant rise in the levels of IL-1, IL-6, IL-8, TNF-α, MMP-11, ICAM-1 and VCAM-1 in ACS patients compared to controls whereas significant decrease was recorded in GSH, CAT, SOD, GRx and HDL levels in patients with ACS compared to controls. Conclusion: The present study indicated that the increased serum concentration of inflammatory cytokines and antioxidant reduction may influence the pathogenesis of ACS.
No takes yet. Share an insight, caveat, or question.
Malik et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: