Neonatal sepsis caused by Klebsiella

Klebsiella is one of the most common causes of neonatal sepsis. Cases caused by extended-spectrum β-lactamase-producing Klebsiella strains are of the most relevance. The infections caused by these bacterial strains are resistant to the majority of cephalosporins commonly used in practice and lead to significant mortality. The development of their clinical forms, including severe ones, is determined by a number of virulence factors that include capsular antigen, lipopolysaccharide, pili, and siderophores. Despite the fact that the probability of sepsis is highest in premature infants, full-term ones are equally at risk in the situations associated by the infection due to extended-spectrum β-lactamase-producing Klebsiella. Our investigation of the specific features of the course of neonatal sepsis caused by Klebsiella established that hemorrhagic syndrome evolving in the presence of thrombocytopenia is the most common condition developing in Klebsiella-induced sepsis that determines the severity of a patient’s condition and affects the outcome of the disease.