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May 29, 2015Kazan medical journalOpen Access

«No-reflow» phenomenon: clinical aspects of reperfusion failure

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Key result

The no-reflow phenomenon occurs in 30% or more of patients with acute coronary syndrome undergoing reperfusion therapy, significantly increasing the risk of complications and death.

Population

Patients with acute coronary syndrome undergoing thrombolysis, percutaneous coronary intervention, or…

Design

Review

Authors

MIM M IskhakovDTD R TagirovaNGNatalya Gazizov

Discussion

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Implication

No-reflow in ACS reperfusion signals high complication risk; leaves open optimal prevention strategies for prospective trials.

Structured PICO

P
Population
Patients with acute coronary syndrome undergoing thrombolysis, percutaneous coronary intervention, or coronary artery bypass surgery, and patients undergoing planned endovascular interventions.
I
Intervention
Pharmacological and mechanical strategies for the prevention and treatment of the no-reflow phenomenon (including intracoronary vasodilators such as adenosine and verapamil, systemic antiplatelets such as abciximab, and mechanical thrombus aspiration).
O
Outcome
Incidence, diagnosis, prevention, and treatment of the no-reflow phenomenon.

The no-reflow phenomenon is a critical complication of reperfusion therapy in ACS, necessitating targeted diagnostic approaches (TIMI, MBG) and specific pharmacological or mechanical interventions.

Limitations

  • Lack of large prospective studies for treatments like adenosine and verapamil

Cite This Study

Iskhakov et al. (2015) conducted a review in Acute coronary syndrome, no-reflow phenomenon. Reperfusion therapy and treatments for no-reflow (e.g., adenosine, verapamil, abciximab) was evaluated. The no-reflow phenomenon occurs in 30% or more of patients with acute coronary syndrome undergoing reperfusion therapy, significantly increasing the risk of complications and death.

synapsesocial.com/papers/6a9559f4dc88abd75325ec17https://doi.org/10.17750/kmj2015-391
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