Key result
No reflow post-primary percutaneous coronary intervention in young STEMI patients was significantly associated with major adverse cardiovascular events and higher mortality.
Why the study?
The study aimed to detect no reflow following primary PCI in young STEMI patients and correlate clinical, electrocardiogram, angiographic, and procedural variables with its occurrence.
What are the predictors of no reflow and does it increase MACE and mortality in young patients with STEMI undergoing primary PCI?
Cohort (n=106)
No
What are the predictors of no reflow and does it increase MACE and mortality in young patients with STEMI undergoing primary PCI?
In young patients with STEMI undergoing primary PCI, smoking, low EF, and anterior wall MI are independent predictors of no reflow, which correlates with higher MACE and mortality.
Answers are grounded in this paper and cite their sources.
May identify higher-risk young STEMI patients; leaves open whether no-reflow is modifiable or requires prospective trials.
Background: Acute treatment of ST elevation myocardial infarction (STEMI) is restoration of myocardial perfusion by recanalization of the occluded vessel. Objective: The aim of the present study is to detect no reflow post primary percutaneous coronary intervention (PCI) in young STEMI patients and to correlate clinical, electrocardiogram, angiographic and procedural variables with no reflow. Patients and methods: This Cohort study was conducted in the Cardiology Department, Faculty of Medicine, Zagazig University on 106 young patients with acute myocardial infarction treated with PPCI during the period from January 2021 to April 2022. The patients were divided into 2 groups according to myocardial blush; Group (I) which included 80 patients with normal flow, and Group (II) which included 26 patients with No reflow. Results: We found that No significant difference between the 2 studied groups regarding Initial Thrombolysis in Myocardial Infarction (TIMI) flow 0 or 1. The admission EF was significantly lower among the No Reflow Group and the no reflow group significantly associated with major adverse cardiovascular events (MACE), mortality, smoking, low EF and anterior wall myocardial infarction (AWMI) were independent predictors for no reflow. Conclusions: No reflow in young patient with STEMI could be attributed to novel predictors such as Smoking, low EF and AWMI. This phenomenon was associated with MACE and higher mortality.
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Gad et al. (2022) conducted a cohort in ST elevation myocardial infarction (STEMI) (n=106). No reflow vs. Normal flow was evaluated on Major adverse cardiovascular events (MACE) and mortality. No reflow post-primary percutaneous coronary intervention in young STEMI patients was significantly associated with major adverse cardiovascular events and higher mortality.
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