Key result
Female sex is linked to ~14-fold higher odds of no-reflow after primary PCI in young STEMI.
Why the study?
No-reflow phenomenon has prognostic value in STEMI but has not been extensively investigated in young patients.
What are the independent predictors of no-reflow phenomenon in young patients with STEMI undergoing primary PCI?
Comparison
No-reflow (TIMI 0-2) vs angiographic success (TIMI 3) post-PCI
Design
Observational cohort study
Authors
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Supports risk stratification but should not change practice yet; leaves open whether targeting these factors improves outcomes in young STEMI.
Observational (n=145)
What are the independent predictors of no-reflow phenomenon in young patients with STEMI undergoing primary PCI?
Odds Ratio: 13.79 (95% CI 1.88–101.26)
p-value: p=<0.001
In young patients with STEMI undergoing primary PCI, female gender, longer pain-to-balloon time, high thrombus burden, and specific hematological indices predict no-reflow, while tirofiban use is protective.
Celık et al. (2015) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=145). Clinical and angiographic risk factors (e.g., female gender, pain to balloon time) vs. Patients without the respective risk factors was evaluated on No-reflow phenomenon (TIMI flow grade 0, 1 or 2) (OR 13.79, 95% CI 1.88-101.26, p=<0.001). Female gender (OR 13.79), pain to balloon time, high TIMI thrombus grade, MPV, and PLR were independent predictors of no-reflow in young patients with STEMI after primary PCI.
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