Key result
Flotillin-1 and caveolin-3 regulate insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle cells through spatial and temporal segregation of insulin signaling components.
Population
Skeletal muscle cells and caveolin-3 null myotubes
Design
Preclinical
Authors
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May guide insulin resistance research; leaves open human translation and therapeutic testing.
Flotillin-1 and caveolin-3 are essential for the spatial and temporal regulation of insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle cells.
Fecchi et al. (2006) studied Glucose metabolism in skeletal muscle. Insulin stimulation vs. Unstimulated cells / Caveolin-3 null myotubes was evaluated on GLUT4 translocation and glucose uptake. Flotillin-1 and caveolin-3 regulate insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle cells through spatial and temporal segregation of insulin signaling components.
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