Key result
A natural porcine model of dystrophin insufficiency recapitulates cardinal features of muscular dystrophy, including focal necrosis, elevated creatine kinase, and sudden death.
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Provides a novel large-animal DMD model; extends preclinical options but leaves clinical translation open.
Selsby et al. (2015) conducted a review in Duchenne muscular dystrophy. Porcine models was evaluated. A natural porcine model of dystrophin insufficiency recapitulates cardinal features of muscular dystrophy, including focal necrosis, elevated creatine kinase, and sudden death.
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