What question did this study set out to answer?

To determine whether spinal microstructural deterioration or bone mineral density has a stronger association with prevalent vertebral fractures in patients with type 2 diabetes mellitus.

September 16, 2019PLoS ONEOpen Access

Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus

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Authors

MYMasahiro YamamotoKumamoto Health Science University MYMika YamauchiOno Pharmaceutical (Japan)TSToshitsugu SugimotoKobe Design University

Discussion

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Implication

Cross-sectional study finds trabecular bone score correlates more strongly with vertebral fractures than bone density in type 2 diabetes, indicating that microarchitecture drives bone fragility.

Key Points

To determine whether spinal microstructural deterioration or bone mineral density has a stronger association with prevalent vertebral fractures in patients with type 2 diabetes mellitus.
Retrospective cross-sectional study of 548 Japanese patients with type 2 diabetes (257 postmenopausal women and 291 men aged >50 years) conducted at Shimane University Hospital.
Spinal trabecular bone score (TBS) and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry (DXA) lumbar spine scans.
Prevalent vertebral fractures were identified in 74 of 257 women (28.8%) and 115 of 291 men (39.5%).
BMD correlated with vertebral fractures only in women with a T-score ≤-1.0, whereas low TBS was significantly associated with fractures independently of BMD in both sexes (except men with T-scores >-1.0).
Decision tree analysis confirmed TBS, rather than BMD, as the primary determinant for classifying prevalent vertebral fractures.

Cite This Study

Yamamoto et al. (2019) studied this question.

synapsesocial.com/papers/6a9562ebd44cea3cdd82a0a0 https://doi.org/10.1371/journal.pone.0222571

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Implication

Cross-sectional study finds trabecular bone score correlates more strongly with vertebral fractures than bone density in type 2 diabetes, indicating that microarchitecture drives bone fragility.

Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

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