Key result
Acute pancreatitis was accompanied by myocardial depression (P<0.03) and an elevated cardiac index, with peripheral vasculature reacting normally, unlike the hyperdynamic state seen in cirrhotics.
Why the study?
Does acute pancreatitis cause myocardial depression compared to normal postoperative patients and cirrhotics?
Observational
Does acute pancreatitis cause myocardial depression compared to normal postoperative patients and cirrhotics?
Acute pancreatitis is associated with primary myocardial depression despite an elevated cardiac index, distinguishing its hemodynamic profile from the peripheral shunting seen in cirrhosis.
Myocardial depression may accompany acute pancreatitis; leaves open whether this warrants specific monitoring versus cirrhosis or postoperative states.
Fifteen patients with acute pancreatitis had 68 physiologic cardiopulmonary assessments performed, and they were compared with 61 performed on normal postoperative patients, and 113 on 41 cirrhotics. It was found that the patients with pancreatitis have an elevated cardiac index (CI), which is not due to the hyperdynamic hemodynamic state found in cirrhotics. In spite of this, the Sarnoff curves demonstrated that pancreatitis was accompanied by a myocardial depression p less than 0.03, not found in hyperdynamic cirrhotics. Cirrhotics are unable to increase their oxygen consumption in response to an increase in CI, as do normal patients or those with acute pancreatitis. In cirrhotics the hemodynamic lesion occurs at the capillary level with the opening of arteriovenous shunts which rob the tissues of their nutritive blood supply, while the patient with acute pancreatitis has a primary myocardial depression and his peripheral vasculature reacts like that of a normal person.
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Ito et al. (1981) conducted an observational in Acute pancreatitis. Acute pancreatitis vs. Normal postoperative patients and cirrhotics was evaluated on Myocardial depression on Sarnoff curves (p=<0.03). Acute pancreatitis was accompanied by myocardial depression (P<0.03) and an elevated cardiac index, with peripheral vasculature reacting normally, unlike the hyperdynamic state seen in cirrhotics.
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