Key result
Phosphorylation of glucose is necessary for insulin-dependent mTOR activity in the heart, suggesting a link between intermediary metabolism and cardiac growth.
Population
Isolated working rat heart, isolated cardiomyocytes, and hearts of diabetic rats
Comparison
Metabolic interventions regulating substrate… vs Conditions without glucose or specific metabolic…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open metabolic targeting of cardiac growth for future investigation.
Glucose phosphorylation is necessary for insulin-dependent mTOR activity in the heart, linking intermediary metabolism to cardiac growth.
Sharma et al. (2007) studied Isolated working rat heart and isolated cardiomyocytes. Metabolic interventions regulating substrate metabolism (glucose, 2-deoxyglucose) was evaluated on Phosphorylation of mTOR and its downstream targets (p70S6K and 4EBP1). Phosphorylation of glucose is necessary for insulin-dependent mTOR activity in the heart, suggesting a link between intermediary metabolism and cardiac growth.
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