Key result
Postmortem angiography revealed abnormalities in the blood vessels supplying the sinoatrial node in 28% of subjects with chronic sinoatrial disorder compared to 0% of controls.
Why the study?
Is chronic sinoatrial disorder associated with ischemic abnormalities in the blood vessels supplying the sinoatrial node?
Population
79 postmortem subjects, including 25 with chronic sinoatrial disorder and 54 who died of heart block with…
Comparison
Postmortem angiography of the blood vessels… vs Subjects who died of heart block with normal…
Design
Case-control
Authors
Loading...
Suggests possible ischemic contribution in ~30% of chronic sinoatrial disorder cases; leaves open causality and does not warrant practice change.
Case-Control (n=79)
Is chronic sinoatrial disorder associated with ischemic abnormalities in the blood vessels supplying the sinoatrial node?
Absolute Event Rate: 28% vs 0%
Coronary artery disease may be a contributing factor in about one third of cases of chronic sinoatrial disorder, suggesting an ischemic origin in a subset of patients.
Shaw et al. (1987) conducted a case-control in Chronic sinoatrial disorder (sick sinus syndrome) (n=79). Cardiac ischaemia vs. Controls with normal sinus node function was evaluated on Abnormalities in blood vessels supplying the sinoatrial node. Postmortem angiography revealed abnormalities in the blood vessels supplying the sinoatrial node in 28% of subjects with chronic sinoatrial disorder compared to 0% of controls.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: