Key result
Transfer Entropy analysis of biosignals during head up tilt testing demonstrated significant differences in information transfer between different phases of the test for RRI and SV as drivers.
Why the study?
How does information transfer between cardiovascular biosignals change during different phases of head-up tilt testing in patients with suspected vasovagal syndrome?
Observational (n=80)
How does information transfer between cardiovascular biosignals change during different phases of head-up tilt testing in patients with suspected vasovagal syndrome?
Transfer entropy analysis reveals dynamic shifts in the primary drivers of cardiovascular regulation during different phases of head-up tilt testing in patients with vasovagal syncope.
TE analysis of biosignals during HUTT may clarify autonomic dynamics in vasovagal syncope; leaves open diagnostic or prognostic utility pending validation.
The paper presents an application of Transfer Entropy (TE) to the analysis of information transfer between biosignals (heart rate expressed as R-R intervals (RRI), blood pressure (sBP, dBP) and stroke volume (SV)) measured during head up tilt testing (HUTT) in patients with suspected vasovagal syndrome. The study group comprised of 80 patients who were divided into two groups: the HUTT(+) group consisting of 57 patients who developed syncope during the passive phase of the test and HUTT(-) group consisting of 23 patients who had a negative result of the passive phase and experienced syncope after provocation with nitroglycerin. In both groups the information transfer depends on the phase of the tilt test. In supine position the highest transfer occurred between driver RRI and other components. In upright position it is the driver sBP that plays the crucial role. The pre-syncope phase features the highest information transfer from driver SV to blood pressure components. In each group the comparisons of TE between different phases of HUT test showed significant differences for RRI and SV as drivers.
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Buszko et al. (2019) conducted an observational in Suspected vasovagal syndrome (n=80). Transfer Entropy analysis of biosignals during head up tilt testing vs. Different phases of the tilt test was evaluated on Information transfer (Transfer Entropy) between biosignals (RRI, sBP, dBP, SV). Transfer Entropy analysis of biosignals during head up tilt testing demonstrated significant differences in information transfer between different phases of the test for RRI and SV as drivers.
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