Asymmetric Transformation of (RS)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid via Salt Formation with (1S)-10-Camphorsulfonic Acid

This is the authors' abstract. We don't add key points for this paper.

Asymmetric transformation of (RS)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid [(RS)-TIC] by use of (1S)-10-camphorsulfonic acid [(S)-CS] as a resolving agent gave a salt of (S)-TIC with (S)-CS with 90% optical purity in hexanoic acid. The TIC obtained from the salt was purified to give optically pure (S)-TIC in 80% yield based on the starting (RS)-TIC.