Key result
In rats, Fe-NTA promoted DEN-induced renal tumorigenesis, increasing tumor incidence to 71% compared to 0% in saline or DEN alone groups, alongside inducing oxidative stress.
Authors
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Preclinical data implicate oxidative stress in renal tumorigenesis; hypothesis-generating and should not change clinical practice.
Absolute Event Rate: 71% vs 0%
Mohammad Athar (1998) studied Renal tumorigenesis. Ferric nitrilotriacetate (Fe-NTA) vs. Saline alone or DEN alone was evaluated on Tumor incidence. In rats, Fe-NTA promoted DEN-induced renal tumorigenesis, increasing tumor incidence to 71% compared to 0% in saline or DEN alone groups, alongside inducing oxidative stress.
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