Several cutaneous disorders are characterized by keratinocyte expression of HLA‐DR. Using an immunohistochemical assay we have observed that expression is maximal where the dermal lymphocytic infiltrate is most intense. This finding is consistent with induction of keratinocyte HLA‐DR expression by gamma‐interferon, released by activated T‐lymphocytes. In atopic dermatitis and psoriasis, where T‐lymphocytes are also observed within the infiltrate, keratinocytes do not express HLA‐DR.
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Barker et al. (1987) studied this question.
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