Key result
Fontan physiology was associated with significantly higher hepatic stiffness compared to controls (15.6 vs 5.5 kPa, P<0.0001), correlating with ventricular end-diastolic pressure and fibrosis.
Why the study?
Does Fontan physiology alter hepatic stiffness and vascular Doppler indices compared to healthy controls?
Cross-Sectional (n=106)
Does Fontan physiology alter hepatic stiffness and vascular Doppler indices compared to healthy controls?
Absolute Event Rate: 15.6% vs 5.5%
p-value: p=<0.0001
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Fontan physiology is associated with significantly increased hepatic stiffness and abnormal vascular flow patterns, which correlate with elevated ventricular end-diastolic pressures and fibrotic changes.
Kutty et al. (2013) conducted a cross-sectional in Fontan palliation of congenital heart disease (n=106). Fontan physiology vs. Controls was evaluated on Hepatic stiffness (p=<0.0001). Fontan physiology was associated with significantly higher hepatic stiffness compared to controls (15.6 vs 5.5 kPa, P<0.0001), correlating with ventricular end-diastolic pressure and fibrosis.
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