Simple two-group model for Rayleigh and Raman optical activity

Rayleigh and Raman circular intensity differentials are calculated for a dissymmetric molecule comprised of two neutral optically inactive groups. The dominant mechanism has no counterpart in optical rotation, being of longer range than Kirkwood's dynamic-coupling interaction that leads to optical rotation. Differential scattering increases with increasing separation of the two groups, whereas optical rotation decreases. Predicted magnitudes are of the order of those observed. The signs of the effects give the absolute configuration of the molecule.