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The feeding of 100 mg of aureomycin daily to lambs resulted in markedly decreased feed consumption and weight loss. Bacterial counts of rumen contents of lambs fed aureomycin and aureomycin plus vitamins was much higher than control animals, indicating that perhaps the aureomycin had destroyed certain strains of bacteria, thereby, eliminating a normal competitive environment and permitting less desirable strain of bacteria to multiply.
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Colby et al. (1950) studied this question.
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