Amoxicillin is often implemented in Helicobacter pyloritreatment protocols. To date, amoxicillin-resistant H. pylori strains have rarely been detected, and only a total of 14 have been reported in the literature (1). Conspicuously, complete loss of the resistant phenotype was observed after these strains were stored at −80°C. Only one amoxicillin-resistantH. pylori strain has been isolated, in The Netherlands, in which in contrast, the amoxicillin resistance remained stable after repeated cycles of freezing and culture (5). The MIC for this strain was 8 μg/ml, which is relatively low.
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Han et al. (1999) studied this question.