Key result
E-cigarette use and tobacco smoking show no association with altered resting HRV after overnight abstinence.
Why the study?
The study was conducted to examine differences in heart rate variability parameters, hemodynamic parameters, and serum cotinine levels across tobacco smokers, e-cigarette users, and non-smokers.
Does e-cigarette and tobacco use alter heart rate variability, hemodynamic parameters, and serum cotinine levels in healthy adults compared to non-smokers?
Case-Control (n=90)
No
Does e-cigarette and tobacco use alter heart rate variability, hemodynamic parameters, and serum cotinine levels in healthy adults compared to non-smokers?
In healthy young adults, resting heart rate variability and serum cotinine levels did not differ significantly between e-cigarette users, tobacco smokers, and non-smokers after 12 hours of abstinence.
Answers are grounded in this paper and cite their sources.
No HRV differences after abstinence in healthy users; leaves open autonomic effects with ongoing use or in higher-risk groups.
This study aims to examine heart rate variability (HRV) parameters, hemodynamic parameters, and serum cotinine levels difference across the following groups: tobacco smokers, e-cigarette users and non-smokers. This study explicitly examined healthy people. Ninety healthy volunteers, aged between 18 and 45, were enrolled in the study. Participants were divided into three groups of thirty each: e-cigarette users, tobacco smokers and non-smokers. HRV data were examined in both the frequency and temporal domains. Additionally, statistical analyses were performed in Python 3.8 using the scikit-learn, pandas, and SciPy packages. Tobacco smokers had a significantly longer smoking history than e-cigarette users (p = 0.027). The baseline systolic blood pressure (SBP) and mean blood pressure (MBP) of the groups varied considerably (p = 0.037 and p = 0.021, respectively), with the non-smoker group exhibiting significantly higher SBP and MBP. For diastolic blood pressure (DBP), the change was borderline (p = 0.073) but nearly significant. All HRV variables displayed standard deviation of normal-to-normal intervals (SDNN): -0.73 ms, root mean square of successive differences (RMSSD): -0.86 ms, proportion of consecutive RR intervals that is different by more than 50 ms (pNN50): -0.60% year and triangular interpolation of normal-to-normal intervals (TINN): -4.07 ms annually as age increased (all p ≤ 0.01). No statistically significant differences in cotinine levels or HRV indices were observed among tobacco smokers, e-cigarette users and non-smokers in this exploratory study. The long-term effects of nicotine products require more research, including longitudinal designs, higher cohort sizes and other physiological and biochemical inflammatory indicators, such as endothelial function markers and cytokines.
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Çamkıran et al. (2026) conducted a case-control in Healthy (n=90). E-cigarette use and tobacco smoking vs. Non-smokers was evaluated on Heart rate variability (HRV) parameters (p=>0.2). E-cigarette use and tobacco smoking were not associated with statistically significant differences in resting heart rate variability indices compared to non-smokers after 12 hours of abstinence.
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