Key result
Aerobic exercise significantly improved mid-wall fractional shortening and decreased NOX2 and NOX4 gene expression in the diaphragm muscle of rats with aortic stenosis-induced heart failure.
Why the study?
The influence of aerobic physical exercise on oxidative stress-associated gene expression in the diaphragm muscle during aortic stenosis-induced heart failure was evaluated.
Does aerobic exercise improve cardiac function and oxidative stress biomarkers in rats with aortic stenosis-induced heart failure?
Does aerobic exercise improve cardiac function and oxidative stress biomarkers in rats with aortic stenosis-induced heart failure?
Absolute Event Rate: 53.75% vs 46.91%
p-value: p=<0.05
Aerobic exercise ameliorates systolic dysfunction and reduces oxidative stress biomarkers in the diaphragm muscle of rats with aortic stenosis-induced heart failure.
Hypothesis-generating for aerobic exercise in experimental AS-HF; human trials needed before clinical translation.
We evaluated the influence of aerobic physical exercise (EX) on gene-encoding proteins associated with oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure (HF). Wistar male rats were divided into four groups: Control sedentary (C); Control exercise (C-Ex); Sedentary aortic stenosis (AS); Aortic stenosis exercise (AS-Ex). Exercised rats trained 5 times a week for 10 weeks on a treadmill. Statistical analysis was performed by ANOVA or Kruskal–Wallis test. In the final echocardiogram, animals with aortic stenosis subjected to exercise demonstrated improvement in systolic function compared to the sedentary aortic stenosis group. In diaphragm muscle, the activity of antioxidant enzymes, malondialdehyde malondialdehyde concentration, protein carbonylation, and protein expression of p65 and its inhibitor IκB did not differ between groups. Alterations in gene expression of sources that generate reactive species of oxygen were observed in AS-Ex group, which showed decreased mRNA abundance of NOX2 and NOX4 compared to the aortic stenosis group (p < 0.05). We concluded that aerobic exercise has a positive impact during heart failure, ameliorating systolic dysfunction and biomarkers of oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure.
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Gomes et al. (2023) studied Aortic stenosis-induced heart failure (n=32). Aerobic physical exercise vs. Sedentary was evaluated on Mid-wall fractional shortening (MFS %) (p=<0.05). Aerobic exercise significantly improved mid-wall fractional shortening and decreased NOX2 and NOX4 gene expression in the diaphragm muscle of rats with aortic stenosis-induced heart failure.
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