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A parylene nanpore was built into multichannel microfluidic devices and a single protein channel was reconstituted in a bilayer lipid membrane (BLM) on the pore. Although BLMs on micropores used for channel recordings are usually too unstable for the exchange of solutions between the upper and lower sides, the BLMs formed in our nanopores were stable enough to permit solution exchange.
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Kawano et al. (2010) studied this question.
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