Key result
High BMI (>25) in postmenopausal women was significantly associated with increased hypertension, higher triglycerides, higher fasting glucose (all P<0.001), and lower HDL-C levels.
Why the study?
Does high BMI increase cardiovascular risk factors (blood pressure, lipids, glucose) in postmenopausal Brazilian women?
Cross-Sectional (n=5,027)
Does high BMI increase cardiovascular risk factors (blood pressure, lipids, glucose) in postmenopausal Brazilian women?
p-value: p=<0.001
High BMI is highly prevalent among Brazilian postmenopausal women and is significantly associated with adverse cardiovascular risk factors including hypertension, dyslipidemia, and elevated fasting glucose.
May warrant enhanced cardiometabolic surveillance in overweight postmenopausal women; leaves open causality pending prospective studies.
OBJECTIVES: To evaluate the frequency of obesity in postmenopausal women and assess the potential effects of increased body mass index (BMI) on lipoprotein profile and on risk factors for arterial hypertension and diabetes. DESIGN: A cross-sectional study was conducted with 5027 postmenopausal Brazilian women. Analyses were performed of BMI and cardiovascular factors (systemic blood pressure [BP], total cholesterol, low-density lipoprotein, high-density lipoprotein [HDL-C], triglyceride, and fast glucose). The statistical analysis included the chi-square and Mann-Whitney tests. The significance level was set at 5%. RESULTS: Obesity (BMI >30) in our study characterized approximately 30% of the 5027 postmenopausal women. The comparison of patients with normal BMI and those with high BMI showed that high BMI had a significant negative effect on BP, as evidenced by the increased frequency of hypertension in overweight and obese patients (>25) (p < 0.001), that it also negatively and significantly affected triglyceride (p < 0.001) and fast glucose levels (p < 0.001), and that it was linked significantly to low levels of HDL-C. CONCLUSION: Our data showed the high frequency of obesity in our population and of the cardiovascular risks (glucose, systemic arterial hypertension, and low HDL-C) associated with high BMI.
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Bagnoli et al. (2014) conducted a cross-sectional in Obesity and metabolic disorder (n=5,027). High body mass index (BMI >25) vs. Normal BMI was evaluated on Frequency of obesity and effects of increased BMI on lipoprotein profile, arterial hypertension, and diabetes risk factors (p=<0.001). High BMI (>25) in postmenopausal women was significantly associated with increased hypertension, higher triglycerides, higher fasting glucose (all P<0.001), and lower HDL-C levels.
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