Key result
High-sensitivity troponin I levels associated with increased 30-day mortality after cardiac surgery were 5670 ng/L for isolated CABG/AVR and 12,981 ng/L for other surgeries.
Why the study?
Consensus recommendations for cardiac troponin thresholds defining perioperative myocardial infarction and periprocedural injury after cardiac surgery vary widely, with limited supporting evidence.
What threshold of peak high-sensitivity troponin I after cardiac surgery predicts 30-day mortality in adult patients?
Population
13,862 patients 18 years or older undergoing cardiac surgery
Comparison
Peak postoperative high-sensitivity cardiac troponin I levels
Design
International prospective cohort study
Follow-up
30 days
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Troponin thresholds tied to 30-day mortality exceed current recommendations; leaves open whether periprocedural injury definitions need revision.
Cohort (n=13,862)
Yes
What threshold of peak high-sensitivity troponin I after cardiac surgery predicts 30-day mortality in adult patients?
High-sensitivity troponin I thresholds associated with increased 30-day mortality after cardiac surgery are substantially higher (218 to 499 times the upper reference limit) than currently recommended definitions for periprocedural myocardial injury.
A 2022 study conducted a cohort in Cardiac surgery (n=13,862). High-sensitivity cardiac troponin I levels was evaluated on 30-day mortality. High-sensitivity troponin I levels associated with increased 30-day mortality after cardiac surgery were 5670 ng/L for isolated CABG/AVR and 12,981 ng/L for other surgeries.
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