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January 1, 1999Toxicologic Pathology

Correlation of Toxicity and Pharmacokinetic Properties of a Phosphorothioate Oligonucleotide Designed to Inhibit ICAM-1

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Authors

SHScott P. HenryIonis Pharmaceuticals (United States)MTMichael V. TemplinCharles River Laboratories (United States)NGNancy A. GillettCharles River Laboratories (United States)

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Henry et al. (1999) studied this question.

synapsesocial.com/papers/6a957249cd304312aafa82e7https://doi.org/10.1177/019262339902700117
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  1. 1CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.1996 · 1,489 citations
  2. 2Evaluation of the Toxicity of ISIS 2302, a Phosphorothioate Oligonucleotide, in a 4-Week Study in CD-1 Mice1997 · 95 citations