Key result
Chemotherapy in children treated for malignancies resulted in the absence of protective antibody titers for hepatitis B (46%), mumps (26%), measles (25%), rubella (24%), tetanus (14%), and polio (7%).
Why the study?
Does chemotherapy reduce protective antibody titers to vaccine-preventable diseases in children treated for malignancies?
Population
192 children who were alive and well after being treated for pediatric malignancies.
Design
Cohort
Authors
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Serologic monitoring may be considered after chemotherapy in pediatric cancer patients; leaves open whether routine revaccination improves clinical outcomes.
Observational (n=192)
Does chemotherapy reduce protective antibody titers to vaccine-preventable diseases in children treated for malignancies?
Chemotherapy induces loss of protective antibody titers in children with malignancies, which can be effectively restored with booster vaccinations.
Zignol et al. (2004) conducted an observational in pediatric malignancies (n=192). Chemotherapy was evaluated on Absence of protective serum antibody titers for hepatitis B, measles, mumps, rubella, tetanus, and polio. Chemotherapy in children treated for malignancies resulted in the absence of protective antibody titers for hepatitis B (46%), mumps (26%), measles (25%), rubella (24%), tetanus (14%), and polio (7%).
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