Key result
Predialysis patients were prescribed a mean of 8.22 medications per patient, with medication use significantly increasing as renal function worsened (P<0.001).
Observational (n=615)
No
p-value: p=<0.001
Malaysian predialysis CKD patients experience high polypharmacy that increases with disease severity, alongside underutilization of key therapies like RAAS blockers.
Describes prescribing patterns in predialysis CKD; leaves open whether patterns optimize outcomes or require prospective validation.
Chronic kidney disease (CKD) patients suffer from multiple comorbidities and complications as a cause or consequence of kidney disease. Information regarding medication- prescribing patterns in predialysis patients is sparse. We conducted a retrospective study to evaluate the medication prescription patterns among predialysis patients. Medical records (both paper based and computerized) of patients at CKD Resource Centre, Hospital Universiti Sains Malaysia, were reviewed. A total of 615 eligible cases were included in the study. The mean number of medications prescribed per patient was 8.22 ± 2.81, and medication use was correlated to the renal function (stage 3a < stage 3b < stage 4 < stage 5; P <0.001). The top three prescribed medication groups were found to be lipid-lowering agents, calcium channel blockers, and antiplatelet agents. Some medication classes such as nonaluminum/noncalcium phosphate binders, erythropoietin-stimulating agents, and renin-angiotensin-aldosterone system blockers, particularly in advanced stage, were found to be underutilized. In conclusion, predialysis patients are prescribed a large number of medications. Our findings highlight the need for assessing the impact of current medication-prescribing patterns on morbidity and mortality rates in Malaysian predialysis population.
No takes yet. Share an insight, caveat, or question.
Salman et al. (2017) conducted an observational in Chronic kidney disease (predialysis) (n=615). Medication prescription patterns was evaluated on Number of medications prescribed per patient (p=<0.001). Predialysis patients were prescribed a mean of 8.22 medications per patient, with medication use significantly increasing as renal function worsened (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: