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Chiral 2-(N-phosphinopyrrol-2-2)oxazolines (PyrPHOX ligands) are readily prepared from 2-cyanopyrrole by condensation with a chiral amino alcohol and subsequent reaction with dialkyl- or diaryl-chlorophosphines. Iridium complexes of these ligands proved to be highly efficient catalysts for the enantioselective hydrogenation of olefins. With unfunctionalized arylalkenes and ethyl cinnamate enantiomeric excesses of 70–99% were obtained.
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Cozzi et al. (2001) studied this question.
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