Correlation Between Maternal Serum Thyroid Profile And Preeclampsia At or Above 36 wks Gestation A Prospective Comparative Observational Study

The present study examines whether maternal thyroid hormone function during later weeks of gestation is related with preeclampsia in a cross sectional view. Methods: This hospital based observational, prospective comparative study was conducted in the Dept. of Obs and Gynae , Bankura Sammilani Medical College and Hospital, Bankura, India ( under West Bengal University of Health Sciences) from April 2014 to March 2015. 200 primigravida mothers attending OPD/admitted in indoor matched with age and parity of gestational age 36 to 41 wks were included in the study in two groups -Group A-Normotensive (N=100) And Group B-Preeclamptic (N=100). Thyroid hormones triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh) were evaluated in both the groups. Results: Mean serum TSH in the normotensive group (A) was 1.690.34 IU/ml vs. mean serum TSH in the preeclamptic group (B) was 4.391.85IU/ml. (P< 0.001), which is statistically significant. However, the mean value of thyroid hormones was in normal range. The risk of having LOW BIRTH WEIGHT (LBW) babies was 2.78 times more in mothers with elevated TSH level in comparison to mothers with normal TSH level. Conclusion: The current study revealed that elevated TSH level is associated with preeclampsia and low birth weight (LBW) babies. So there is a strong potential to use maternal serum TSH level to predict preeclampsia and LBW babies.