Key result
Oral cimetidine improved the accuracy of creatinine clearance compared with placebo in patients with lupus nephritis (CDTPA-to-CCr ratio 1.07 vs 1.33; P<0.05).
Why the study?
Does short-term oral cimetidine improve the accuracy and precision of creatinine clearance in patients with lupus nephritis?
Population
13 patients with lupus nephritis with mild renal insufficiency.
Comparison
Cimetidine tablets, 400 mg oral four times daily… vs Placebo tablets four times daily for 2 days.
Design
RCT, crossover, Double-blind
Follow-up
2 days per treatment period
Authors
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Supports short-term cimetidine to improve CCr accuracy in lupus nephritis; extends practical GFR estimation options beyond costly methods.
RCT (n=13)
Double-blind
Does short-term oral cimetidine improve the accuracy and precision of creatinine clearance in patients with lupus nephritis?
Absolute Event Rate: 1.07% vs 1.33%
p-value: p=<0.05
Short-term oral cimetidine improves the accuracy and precision of creatinine clearance for estimating GFR in patients with lupus nephritis, offering a practical alternative to expensive research techniques.
Ronenn Roubenoff (1990) conducted an RCT in Lupus nephritis (n=13). Oral cimetidine vs. Placebo was evaluated on Accuracy of creatinine clearance (CCr), as measured by the CDTPA-to-CCr ratio (p=<0.05). Oral cimetidine improved the accuracy of creatinine clearance compared with placebo in patients with lupus nephritis (CDTPA-to-CCr ratio 1.07 vs 1.33; P<0.05).
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