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We examined the antiviral efficacy of an extract of the marine brown alga, Sargassum hemiphyllum (Turner) C. Agardh that markedly promotes production of interferon β in MG-63 cells in culture. The partially purified fraction from the methanol extract of S. hemiphyllum (Turner) C. Agardh, MC9, was most effective at a concentration of 1 μg/ml, enhancing the productivity approximately 14-fold and twofold in the presence of polyinosinic-polycytidylic acid and the Sendai virus, respectively. Antiviral tests of MC9 revealed the therapeutic efficacy in mice infected with Aujeszky's disease virus. These results suggest that MC9 manifests its antiviral activity by modulating host immunodefense systems.
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Nakano et al. (2005) studied this question.
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