Key result
The Duke Activity Status Index successfully discriminated high-risk individuals with pulmonary arterial hypertension with an AUC of 0.79.
Why the study?
Exercise capacity is key to risk assessment in pulmonary arterial hypertension, prompting investigation into whether the Duke Activity Status Index associates with peakVO2 and discriminates high-risk patients.
Does the Duke Activity Status Index (DASI) correlate with peakVO2 and discriminate high-risk individuals in patients with pulmonary arterial hypertension?
Cross-Sectional (n=89)
Does the Duke Activity Status Index (DASI) correlate with peakVO2 and discriminate high-risk individuals in patients with pulmonary arterial hypertension?
The Duke Activity Status Index is a useful, non-invasive tool for assessing exercise capacity and identifying high-risk patients with pulmonary arterial hypertension.
Answers are grounded in this paper and cite their sources.
DASI may aid noninvasive risk stratification in PAH; leaves open prospective validation against peakVO2.
Exercise capacity is an important component of risk assessment for pulmonary arterial hypertension (PAH). We investigated the association of the Duke Activity Status Index (DASI) with peak oxygen consumption (peakVO2) and explored whether the DASI can discriminate the high-risk individuals in patients with PAH, according to peakVO2 < 11 mL/min/kg. A total of 89 patients were evaluated using cardiopulmonary exercise testing (CPET) and DASI. The correlation between the DASI and peakVO2 was measured by univariate analysis, and a receiver operating characteristic (ROC) curve analysis was conducted. The DASI was correlated with peakVO2 in the univariate analysis. The ROC curve analysis revealed that the DASI had a discriminative value for identifying the individuals with a high risk in PAH patients (p < 0.001), with an area under ROC curve (AUC) of 0.79 (95% CI: 0.67–0.92). Similar results were observed in patients with PAH associated with congenital heart disease (CHD–PAH), (p = 0.001), with an AUC of 0.80 (95% CI: 0.658–0.947). Therefore, DASI reflects exercise capacity in patients with PAH and has good ability to discriminate patients with a low risk and a high risk, and it may be included in the risk assessment of PAH.
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Zhou et al. (2023) conducted a cross-sectional in Pulmonary Arterial Hypertension (n=89). Duke Activity Status Index (DASI) was evaluated on Discrimination of high-risk individuals (peakVO2 < 11 mL/min/kg) (AUC 0.79, 95% CI 0.67-0.92, p=< 0.001). The Duke Activity Status Index successfully discriminated high-risk individuals with pulmonary arterial hypertension with an AUC of 0.79.
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