Comparative study of platelet-rich plasma and hyaluronic acid in osteoarthritis of knee: A clinical study

Objectives The objective of this clinical study was to compare the effectiveness of intra-articular (IA) injections of platelet-rich plasma (PRP) with that of hyaluronic acid (HA) in people with symptomatic knee osteoarthritis (OA) over each follow-up interval. Material and Methods A randomised controlled trial included 60 patients. The National Health and Medical Research Council Clinical Trial Centre permuted a computer-generated random number sequence. After telephone, radiographic, and laboratory screening, administered three weekly IA knee injections. Blood was drawn to prevent blindness. Each weekly visit produced fresh PRP samples. Results PRP was compared to a HA in a study examining the treatment of knee OA, and the results are displayed. The two groups reported comparable levels of knee discomfort at baseline but after two months. Patients receiving PRP were likelier to report overall improvement at 12 months. Conclusion This study reveals that PRP is more effective than HA in treating patients with moderate to mild radiographic PRP-alone therapy in pain relief and function improvement for patients with Knee OA who are experiencing symptoms.