Cardiac Troponins T and I Before and After Renal Transplantation
Key result
A modified second-generation cTnT assay yielded fewer falsely positive results in pretransplant renal failure patients (15%) compared to the first-generation assay (54%).
Why the study?
Do different cardiac troponin assays (original cTnT, modified cTnT, cTnI) yield different rates of abnormal results in patients before and after renal transplantation?
Population
26 patients with chronic renal failure undergoing renal transplantation.
Comparison
Measurement of cardiac troponins using original… vs Pre-transplant troponin values.
Design
Cohort
Follow-up
6 weeks after collection of the posttransplant sample
Authors
Discussion
Loading...
Member takes
Implication
May reduce false-positive cTnT results in renal failure; leaves open effects on post-transplant decisions and prognosis.
Study Design
Type
Observational (n=26)
Structured PICO
Do different cardiac troponin assays (original cTnT, modified cTnT, cTnI) yield different rates of abnormal results in patients before and after renal transplantation?
P
Population
26 patients evaluated before and after renal transplantation with a 6-week retrospective clinical follow-up for cardiac events.
E
Exposure
Measurement of cardiac troponins using original cTnT, modified second-generation cTnT, and cTnI assays before and after renal transplantation.
C
Comparator
Pre-transplant troponin values.
O
Outcome
Troponin concentrations (original cTnT, modified cTnT, cTnI) and incidence of acute myocardial infarction (AMI) or cardiac death at 6 weeks post-transplant.surrogate
Main Result
Absolute Event Rate: 15% vs 54%
The first-generation cTnT assay produces falsely high results in renal failure patients, which is largely corrected by the second-generation assay, and abnormal results do not necessarily reflect poor short-term prognosis in this population.
Limitations
- Limited study size
- Small sample size (limited study)
Cite This Study
Wu et al. (1997) conducted an observational in Renal failure requiring transplantation (n=26). Second-generation ELISA cTnT assay vs. First-generation cTnT assay was evaluated on Positive cTnT results in pretransplant samples. A modified second-generation cTnT assay yielded fewer falsely positive results in pretransplant renal failure patients (15%) compared to the first-generation assay (54%).