Key result
Human coxsackievirus and adenovirus receptor (HCAR) expression in human umbilical vein endothelial cells increases with culture confluence and is unaltered by coxsackievirus B infection.
Endothelial cells regulate coxsackievirus and adenovirus receptor expression based on cell density, but do not down-regulate it in response to coxsackievirus B infection, providing insight into viral pathogenesis.
Hypothesis-generating for endothelial coxsackievirus B susceptibility; leaves open density effects on in vivo pathogenesis.
Primary cultures of human umbilical vein endothelial cells (HUVEC) express the human coxsackievirus and adenovirus receptor (HCAR). Whereas HCAR expression in HeLa cells was constant with respect to cell density, HCAR expression in HUVEC increased with culture confluence. HCAR expression in HUVEC was not quantitatively altered by infection with coxsackievirus B.
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Carson et al. (1999) studied this question. Human coxsackievirus and adenovirus receptor (HCAR) expression in human umbilical vein endothelial cells increases with culture confluence and is unaltered by coxsackievirus B infection.
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