Key result
Hyperpolarizing ('off') voltage-clamp steps in frog muscle fibres produced q gamma charge transients that were rapid decays lasting 10-15 ms, in contrast to prolonged time courses in 'on' steps.
Population
frog muscle fibres (Rana temporaria)
Design
Preclinical
Authors
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Rapid 'off' q gamma kinetics in frog fibers extend charge-movement models; leaves open mammalian relevance and clinical translation.
In frog skeletal muscle, the 'off' responses of the q gamma charge component are consistently rapid decays, contrasting with their varied pattern in 'on' transients.
Christopher Huang (1984) studied this question. Hyperpolarizing ('off') voltage-clamp steps vs. Depolarizing ('on') steps was evaluated on Time course of 'off' tails of intramembrane charge movements (q gamma charge). Hyperpolarizing ('off') voltage-clamp steps in frog muscle fibres produced q gamma charge transients that were rapid decays lasting 10-15 ms, in contrast to prolonged time courses in 'on' steps.
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