Key result
Amlodipine use in paediatric patients can cause generalised oedema, which was shown to resolve upon discontinuation of the medication in four cases.
Why the study?
Does amlodipine cause generalized edema in pediatric patients?
Case Report (n=4)
Does amlodipine cause generalized edema in pediatric patients?
Amlodipine can cause generalized edema in pediatric patients, which resolves upon discontinuation of the medication.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to consider amlodipine in paediatric oedema; case reports leave open questions of incidence and causality.
AIM: Amlodipine, a calcium channel blocker became one of the most popular antihypertensive medications used in the paediatric population. This is mainly due to its long half-life making it easy to use as a single daily dose. Amlodipine is associated with common side effects like flushing, headache and dizziness. The incidence of amlodipine-related oedema was noted to be lower in the paediatric population compared to adults. We emphasise the importance of monitoring the development of oedema in patients treated with amlodipine. METHODS: Hereby, we report four paediatric cases with amlodipine-related generalised oedema. CONCLUSION: Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
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Rabah et al. (2017) conducted a case report in Amlodipine-related generalised oedema (n=4). Amlodipine was evaluated on Resolution of oedema. Amlodipine use in paediatric patients can cause generalised oedema, which was shown to resolve upon discontinuation of the medication in four cases.
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