Evaluation of anti-stressor protection of the different methods of general anesthesia at an adenotomy in children

Aim. An evaluation of the level of anti-stressor protection of the different methods of general anesthesia at adenotomy in children by the study of indicators of hemodynamics and the level of “stress markers”.Materials and methods. Research includes 60 children 6-11 years old who underwent adenotomy. Patients were divided into 3 groups: I group (n=21) – were operated in conditions of intravenous anesthesia on the basis of propofol in combination with fentanyl; II group (n=19) – were operated in conditions of an inhalational anesthesia with sevoflurane in combination with fentanyl and sodium metamizol; III group (n=20) – were operated in conditions of intravenous anesthesia on the basis of sodium thiopental in combination with fentanyl. The differences considered reliable at р<0,0 using t-criterion of Student. Coefficient of correlation was defined according to Pirson.Results. It was revealed that in all groups at all stages of research the levels of insulin and glycemia didn’t exceed the limits of the laboratory norm. At the stage of traumatic moment of an operation it was marked an increase of the cortisol level in the I group (p>0,05), but this increase was in the limits of laboratory norm, in II and III groups was the more essential tendency to the growth of cortisol level but it wasn’t marked a reliable difference in groups between the stages (p>0,05). At the stage of extubation of trachea in patients of II and III groups it was marked a tendency to decrease of the cortisol level but the next morning after operation there were no reliable intergroup differences of cortisol level. The stable correlations between the “stress markers” and clinical indicators weren’t fixed. BIS-monitoring in children in conditions of general anesthesia with sodium thiopental needs the more precise investigation.Conclusions. Anesthesia with the use of propofol in combination with fentanyl (2mkg/kg) ensures the most pronounced level of anti-stressor protection at an adenotomy in children