Pathophysiology of Osgood-Schlatter Disease: Does Vitamin D have a Role?

Objective: The objectives of this study were to determine the vitamin D status in a sample of Tunisian children with Osgood-Schlatter disease (OSD).Patients and methods: We performed a prospective study including normal and healthy children presented with OSD. An assessment of the status of vitamin D measuring serum concentrations of 25-hydroxy vitamin D, was done for all patients using the chemiluminescence immunoassays technique.Results: During the study period, 80 children have been enrolled and the mean age was 13.6 years. All children had low-level vitamin D with a mean of 19.2 ng/mL (range of 5-27 ng/mL). All the children were then placed under a vitamin D substitution. At follow-up, majority of knees were asymptomatic and functioned unaltered with all activities. Radiologically, all patients showed healing of the tibial tuberosity secondary ossification center.Conclusion: In our study, all children with OSD had low-level vitamin D and after supplementation of vitamin D, the symptoms were resolved. Vitamin D deficiency screening should be instituted among children at risk of OSD and early vitamin D supplementation should be started for prevention.