Key result
The CHAPS trial is a protocol for a randomized controlled trial to evaluate the effect of graduated compression stockings in preventing post-thrombotic syndrome after deep vein thrombosis.
Why the study?
Up to 50% of patients develop post-thrombotic syndrome after an above-knee DVT, prompting investigation into whether graduated compression stockings can prevent it.
Does the addition of graduated compression stockings to standard anticoagulation prevent post-thrombotic syndrome in adults with a first above-knee DVT?
RCT
Yes
Does the addition of graduated compression stockings to standard anticoagulation prevent post-thrombotic syndrome in adults with a first above-knee DVT?
This protocol outlines a pragmatic, multicenter RCT to determine if graduated compression stockings added to standard anticoagulation prevent post-thrombotic syndrome in adults with a first above-knee DVT.
Answers are grounded in this paper and cite their sources.
No practice change yet; CHAPS RCT protocol leaves open whether graduated compression stockings prevent post-thrombotic syndrome after DVT.
INTRODUCTION: Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT. METHODS AND ANALYSIS: Pragmatic, UK multicentre randomised trial in adults with first above knee DVT. The standard of care arm is anticoagulation. The intervention arm will receive anticoagulation plus stockings (European class II, 23-32 mm Hg compression) worn for a median of 18 months. The primary endpoint is PTS using the Villalta score. Analysis of this will be through a time to event approach and cumulative incidence at median 6, 12 and 18 months. An ongoing process evaluation will examine factors contributing to adherence to stockings to understand if and how the behavioural interventions were effective. ETHICS AND DISSEMINATION: UK research ethics committee approval (reference 19/LO/1585). Dissemination though the charity Thrombosis UK, the Imperial College London website, peer-reviewed publications and international conferences. TRIAL REGISTRATION NUMBER: ISRCTN registration number 73041168.
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Thapar et al. (2021) conducted an RCT in First above knee deep vein thrombosis (DVT). Graduated compression stockings plus anticoagulation vs. Anticoagulation alone was evaluated on Post-thrombotic syndrome (PTS) using the Villalta score. The CHAPS trial is a protocol for a randomized controlled trial to evaluate the effect of graduated compression stockings in preventing post-thrombotic syndrome after deep vein thrombosis.
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