Key result
Type 2 Diabetes Mellitus may reduce gender-related differences in cardiovascular disease prevalence by fading the vascular protective effects afforded by estrogen in females.
Type 2 Diabetes Mellitus attenuates the cardiovascular protective effects of estrogen in women, explaining their increased risk of vascular dysfunction.
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May explain equalized CVD risk in diabetic women; hypothesis-generating and requires prospective validation before guiding practice.
Gender plays a pivotal role in the onset as well as in the progression of the cardiovascular disease with a higher morbidity and mortality being detected in men with respect to women. Type 2 Diabetes Mellitus (T2DM) may reduce gender-related differences in the prevalence of cardiovascular disease by fading the vascular protective effects afforded by estrogen in females. This article will discuss the role of sex and sex hormones on the incidence and mechanisms involved in vascular dysfunction associated to T2DM, which might explain why women with T2DM lack the vascular protection.
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Dantas et al. (2012) conducted a review in Type 2 Diabetes Mellitus and Cardiovascular Disease. Type 2 Diabetes Mellitus was evaluated. Type 2 Diabetes Mellitus may reduce gender-related differences in cardiovascular disease prevalence by fading the vascular protective effects afforded by estrogen in females.
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