Fixed Drug Eruptions

We believe that the term fixed drug eruption as first applied and interpreted by Brocq is not always employed in the original sense. As a help to a better understanding of such eruptions we are restating the definition of the term fixed so far as it applies to drug eruptions. We submit also a compilation of the different types of fixed eruptions that have been reported, the various drugs and other agents considered responsible for them and some comments on the pathogenesis of such manifestations. HISTORICAL NOTES Soon after 1885, when antipyrine came into use, several observers called attention to eruptions caused by this drug. One type noted was peculiar in that it recurred at the previously affected areas of the skin whenever antipyrine was again ingested. Brocq 1 after observing several cases, designated such cutaneous manifestations as fixed. His description may be summarized as follows: The cutaneous manifestations appeared