Key result
Presentation pattern in ACS patients undergoing PCI affected 1-year mortality, with unadjusted mortality highest in STEMI compared to NSTEMI and unstable angina.
Why the study?
Does the presentation pattern of acute coronary syndrome affect 1-year mortality in patients undergoing percutaneous coronary intervention?
Cohort (n=10,455)
Does the presentation pattern of acute coronary syndrome affect 1-year mortality in patients undergoing percutaneous coronary intervention?
In patients with ACS undergoing PCI, the presentation pattern is an independent predictor of 1-year mortality, with STEMI and NSTEMI carrying significantly higher risk than unstable angina.
Answers are grounded in this paper and cite their sources.
Presentation pattern identifies varying 1-year post-PCI mortality risk in ACS; extends stratification but requires prospective confirmation.
OBJECTIVES: We undertook this study to assess the relationship between presentation pattern and mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention. METHODS: This registry included 10,455 patients with ACS, of whom 2,853 patients had ST-segment elevation myocardial infarction(STEMI), 3,060 patients had non-ST-segment elevation myocardial infarction (NSTEMI) and 4,542 patients had unstable angina. The primary outcome was 1-year mortality. RESULTS: At 1 year there were 976 deaths, 390 (13.7%) among STEMI patients, 366 (12.0%) among NSTEMI patients and 220 (4.8%) among patients with unstable angina (OR = 1.17, 95% CI 1.01-1.35 for STEMI vs. NSTEMI; OR = 3.00, 95% CI 2.56-3.51 for STEMI vs. unstable angina, and OR = 2.58, 95% CI 2.20-3.04 for NSTEMI vs. unstable angina). In the Cox proportional hazards model ACS form was an independent correlate of 1-year mortality (HR = 0.90, 95% CI 0.73-1.13 for STEMI vs. NSTEMI; HR = 1.56, 95% CI 1.13-2.14 for STEMI vs. unstable angina; HR = 1.72, 95% CI 1.30-2.29 for NSTEMI vs. unstable angina). CONCLUSIONS: The presentation pattern affects 1-year mortality in patients with ACS, with unadjusted mortality being highest in patients with STEMI and lowest in patients with unstable angina.
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Ndrepepa et al. (2009) conducted a cohort in Acute coronary syndrome (n=10,455). STEMI presentation vs. NSTEMI presentation was evaluated on 1-year mortality (HR 0.90, 95% CI 0.73-1.13). Presentation pattern in ACS patients undergoing PCI affected 1-year mortality, with unadjusted mortality highest in STEMI compared to NSTEMI and unstable angina.
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