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Case report reports SARS-CoV-2 as a trigger of dermato-neuro syndrome in scleromyxedema, highlighting systemic complications of viral infection.
Scleromyxedema (SMX) is characterized by excessive mucin deposition in connective tissues and skin.1 It shares clinical features with other mucinoses, including generalized myxedema, pre-tibial myxedema, reticular erythematous mucinosis, and scleredema.1 However, diagnosis of SMX is distinguished by the following criteria: absence of thyroid disease, presence of monoclonal gammopathy (classically IgG λ), and cutaneous eruption of waxy papules and plaques, characterized histopathologically by increased dermal mucin, fibroblast proliferation, and fibrosis.
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Fritz et al. (2021) studied this question.
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