What question did this study set out to answer?

To evaluate the immunogenicity and protective efficacy of the conserved surface protein iron surface determinant B (IsdB) as a prophylactic vaccine against Staphylococcus aureus infection.

March 21, 2006Infection and ImmunityOpen Access

A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model

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Authors

NKNelly A. KuklinCompass (United States)DCDesmond ClarkJohnson & Johnson (United States)SSSusan SecoreMerck & Co., Inc., Rahway, NJ, USA (United States)

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Implication

Preclinical evaluation reveals protective immunity and rapid antibody production in mice and macaques, highlighting IsdB as a viable human vaccine candidate.

Key Points

To evaluate the immunogenicity and protective efficacy of the conserved surface protein iron surface determinant B (IsdB) as a prophylactic vaccine against Staphylococcus aureus infection.
Assessed the surface expression and conservation of IsdB across methicillin-sensitive and methicillin-resistant S. aureus clinical isolates.
Tested the immunogenicity and protective efficacy of IsdB formulated with amorphous aluminum hydroxyphosphate sulfate adjuvant in murine sepsis models, including challenge with an IsdB- and HarA-deficient mutant strain.
Measured antibody titer kinetics in rhesus macaques following a single immunization.
IsdB was expressed across all tested clinical isolates, and vaccination elicited reproducible, significant survival protection in murine sepsis models.
Protection in mice was target-specific, demonstrated by the lack of protection against an IsdB- and HarA-deficient mutant S. aureus strain.
A single immunization in rhesus macaques induced a greater than fivefold increase in antibody titers.

Cite This Study

Kuklin et al. (2006) studied this question.

synapsesocial.com/papers/6a958c26aec9be1889e3dc5a https://doi.org/10.1128/iai.74.4.2215-2223.2006

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Implication

Preclinical evaluation reveals protective immunity and rapid antibody production in mice and macaques, highlighting IsdB as a viable human vaccine candidate.

A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model

Discussion

Member takes

Implication

Key Points

Cite This Study

A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model

Discussion

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Implication

Key Points

Cite This Study

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