Answers are grounded in this paper and cite their sources.
Hair samples were collected from 60 patients receiving long-term methadone maintenance: 50 were taking the drug orally and 10 were receiving the drug by intravenous injection. The amount of methadone present in the hair samples was measured using methanolic extraction, derivatization of the extracts with MTBSTFA, followed by electron impact gas chromatography-mass spectrometry operating in selected ion monitoring mode. The limit of quantitation for the assay was 0.4 ng/mg hair. The dose/concentration relationship for methadone in hair was investigated. No interindividual correlation between prescribed dose and concentration of methadone in hair was observed.
No takes yet. Share an insight, caveat, or question.
Paterson et al. (2003) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: