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The effect of multiple sublethal doses of busulfan on the haemopoietic system of the Balb/c mouse was examined. FBC's bone marrow histology and bone marrow progenitor cell assays (CFU-E, BFU-E, CFU-GM and CFU-GEM) were performed. No effect was seen on FBC's or on marrow histology. However there was a significant depletion noted in the number of haemopoietic progenitor cells as measured by in vitro culture.
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McCann et al. (1986) studied this question.
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