Key result
Frailty increases the risk of all-cause death (HR 1.73; 95% CI 1.50-2.00; p<0.001) in patients with heart failure.
Why the study?
The study was conducted to systematically evaluate the effect of frailty on the prognosis of patients with heart failure.
Does frailty increase the risk of all-cause death and unplanned readmission in patients with heart failure?
Meta-Analysis (n=406,269)
Does frailty increase the risk of all-cause death and unplanned readmission in patients with heart failure?
Frailty is a significant predictor of all-cause mortality and unplanned readmissions in patients with heart failure, highlighting the importance of frailty assessment in risk stratification.
Supports incorporating frailty assessment into heart failure risk stratification; reinforces its prognostic value in meta-analysis.
OBJECTIVE: To systematically evaluate the effect of frailty on the prognosis of patients with heart failure. METHODS: Computer searches were conducted on PubMed, Embase, The Cochrane Library, Web of Science, CNKI, Wanfang Data Knowledge Service platform, Weipu full-text database of Chinese scientific and technological journals, and Chinese biomedical literature database from August 12, 2022. After literature screening was completed by two researchers, the data extraction (such as study type, sample size, age of included patients, New York Heart Association (NYHA) Functional Classification, frailty assessment tool, frailty positive rate, outcome indicators, etc.) was performed and the risk of bias in the included studies was assessed. Meta-analysis was performed using Revman 5.4 and Stata 14.0 software. RESULTS: A total of 32 studies were included, including 406,269 patients with heart failure. All included studies were rated high overall quality. The results of meta-analysis showed: Frailty increases the risk of all-cause death in patients with heart failure (hazard ratio [HR] = 1.73, 95% confidence interval [CI]: 1.50 - 2.00, p < 0.001), unplanned readmission (HR = 1.96, 95% CI: 1.21 - 3.17, p = 0.006), and joint endpoint risk (HR = 1.66, 95% CI: 1.48 - 1.86, p < 0.001). CONCLUSION: Current evidence suggests that frailty increases the risk of all-cause death, unplanned readmission, and joint endpoints in patients with heart failure.
No takes yet. Share an insight, caveat, or question.
Xiangying Meng (2024) conducted a meta-analysis in heart failure (n=406,269). Frailty was evaluated on all-cause death (HR 1.73, 95% CI 1.50 - 2.00, p=< 0.001). Frailty increases the risk of all-cause death (HR 1.73; 95% CI 1.50-2.00; p<0.001) in patients with heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: