Many of the chemotactic responses exhibited by Escherichia coli are mediated by a family of inner membrane proteins known as methyl-accepting chemotaxis proteins (MCPs). These relatively simple sensory transducers offer useful models for investigating stimulus detection and transmembrane signaling events at the molecular level. In this paper, we summarize genetic studies aimed at identifying the structural features of MCP molecules that are critical to their various signaling activities.
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Ames et al. (1988) studied this question.