Key result
Immunofluorescence studies demonstrated a differential expression pattern of rEag1 and rEag2 K channels in the somatodendritic region of hippocampal neurons.
No immediate clinical implications; extends basic mapping of Eag channel localization in hippocampal neurons.
Two isoforms of rat ether-a-go-go (Eag) K channels, rEag1 and rEag2, are widely expressed in many regions of the brain. The neurophysiological roles of these channels, however, are unclear. We addressed this issue by studying their subcellular localizations in hippocampal neurons. Immunofluorescence studies using markers for different compartments of neurons demonstrated a differential expression pattern of rEag1 and rEag2 K channels in the somatodendritic region. Furthermore, rEag1 K channels were in close proximity to synaptophysin and densin-180, but not GAD65. Our data suggest that both rEag1 and rEag2 K channels may play a pivotal role in the regulation of the excitability of dendrites and somas, and that rEag1 K channels may modulate the postsynaptic signaling of glutamatergic synapses.
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Jeng et al. (2005) studied this question. rEag1 and rEag2 K channels was evaluated on Subcellular localizations in hippocampal neurons. Immunofluorescence studies demonstrated a differential expression pattern of rEag1 and rEag2 K channels in the somatodendritic region of hippocampal neurons.
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